Pharmacodynamics of teicoplanin against MRSA
نویسندگان
چکیده
منابع مشابه
Pharmacokinetic/pharmacodynamic analysis of teicoplanin in patients with MRSA infections
BACKGROUND Teicoplanin is a glycopeptide antibiotic that has been used to treat serious, invasive infections caused by Gram-positive bacteria. The area under the drug concentration-time curve (AUC)/minimum inhibitory concentration (MIC) was identified as a pharmacokinetic-pharmacodynamic (PK-PD) parameter of glycopeptide antibiotics that correlated with bacteriological responses and clinical ou...
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AFN-1252, a new antimicrobial agent, specifically and potently inhibits fatty acid synthesis in Staphylococcus aureus. We characterized in vivo pharmacokinetic and pharmacodynamic profiles of AFN-1252 administered orally to neutropenic mice inoculated in thighs (∼10(6) CFU) with methicillin-susceptible S. aureus (MSSA) ATCC 29213. Efficacy was also assessed in mice inoculated with MSSA, hospit...
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Clinically useful antibiotics, β-lactams and vancomycin, are known to inhibit bacterial cell wall peptidoglycan synthesis. Methicillin-resistant Staphylococcus aureus (MRSA) has a unique cell wall structure consisting of peptidoglycan and wall teichoic acid. In recent years, new anti-infectious agents (spirohexaline, tripropeptin C, DMPI, CDFI, cyslabdan, 1835F03, and BPH-652) targeting MRSA ce...
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INTRODUCTION Vancomycin (VAN) failures associated with the treatment of complicated methicillin-resistant Staphylococcus aureus (MRSA) infections have been well described. The reported "seesaw effect" demonstrates improved β-lactam activity when VAN and/or daptomycin (DAP) susceptibility decreases. However, there are minimal data comparing ceftaroline (CPT) susceptibility with these agents or t...
متن کاملArbekacin as an Alternative Drug to Teicoplanin for the Treatment of MRSA Infection
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most important pathogen in nosocomial infections. MRSA is mainly treated with antibiotics of the glycopeptide family, such as vancomycin or teicoplanin; however, the minimum in-hibitory concentration of MRSA has recently been increased. 1 The emerging resistance has led to focus on antibiotics from alternative classes. Arbekacin h...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2017
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dkx289